Article

Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy

2024-04-06

Abstract excerpt

Recycling of cellular components through autophagy maintains homeostasis in dynamic nutrient environments, and its dysregulation is linked to several human disorders. Although extensive research has characterized the core mechanisms of autophagy, limited insight into its systems-wide dynamic control has hampered predictive modeling and effective in vivo manipulation. In this study, we mapped the genetic network t...

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Literature Corpus work: 7722936e-0bdd-5664-8314-58863938cf2f
DOI: 10.1101/2024.04.06.588104

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