Article

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability

2023-10-03

Abstract excerpt

Amino acid (AA) availability is a robust determinant of cell growth, through controlling mTORC1 activity 1 . According to the predominant model in the field, AA sufficiency drives the recruitment and activation of mTORC1 on the lysosomal surface by the heterodimeric Rag GTPases, from where it coordinates the majority of cellular processes (reviewed in 2,3 ). Importantly, however, 15 years after its initial disco...

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Literature Corpus work: 52a42247-be4c-5393-b95f-946b3f4b85a2
DOI: 10.1101/2023.10.03.559930

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