Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.

doi:10.1038/ng.3222

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.

Nature genetics - 1 Apr 2015

Crowley James J, Zhabotynsky Vasyl, Sun Wei, Huang Shunping, Pakatci Isa Kemal, Kim Yunjung, Wang Jeremy R, Morgan Andrew P, Calaway John D, Aylor David L, Yun Zaining, Bell Timothy A, Buus Ryan J, Calaway Mark E, Didion John P, Gooch Terry J, Hansen Stephanie D, Robinson Nashiya N, Shaw Ginger D, Spence Jason S, Quackenbush Corey R, Barrick Cordelia J, Nonneman Randal J, Kim Kyungsu, Xenakis James, Xie Yuying, Valdar William, Lenarcic Alan B, Wang Wei, Welsh Catherine E, Fu Chen-Ping, Zhang Zhaojun, Holt James, Guo Zhishan, Threadgill David W, Tarantino Lisa M, Miller Darla R, Zou Fei, McMillan Leonard, Sullivan Patrick F, Pardo-Manuel de Villena Fernando

Abstract excerpt

Complex human traits are influenced by variation in regulatory DNA through mechanisms that are not fully understood. Because regulatory elements are conserved between humans and mice, a thorough annotation of cis regulatory variants in mice could aid in further characterizing these mechanisms. Here we provide a detailed portrait of mouse gene expression across multiple tissues in a three-way diallel. Greater than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Allelic Imbalance

Share to Crosses, Genetic

Share to Dosage Compensation, Genetic

Share to Gene Expression

Share to Genetic Speciation

Share to Mice

Share to Mice, Knockout

Share to Phylogeny

Source

Open in PubMed Open full text

Identifiers

PMID: 25730764
DOI: 10.1038/ng.3222
PMCID: PMC4380817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.PMID 25730764Read ↗

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.Semantic proximity Read ↗

Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.Semantic proximity Read ↗

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.Semantic proximity Read ↗

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolutionSemantic proximity Read ↗

Detection of regulatory variation in mouse genes.Semantic proximity Read ↗

The genetic basis for DNA methylation variation across tissues and development.Semantic proximity Read ↗

The genetic basis for DNA methylation variation across tissues and developmentSemantic proximity Read ↗

Allele-specific expression and eQTL analysis in mouse adipose tissue.Semantic proximity Read ↗

Genomic analysis of allele-specific expression in the mouse liverSemantic proximity Read ↗

Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome.Semantic proximity Read ↗

Sequence and parent-of-origin dependent m6A contribute to allele-specific gene expression.Semantic proximity Read ↗

A survey of allelic imbalance in F1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.