Article
The genetic basis for DNA methylation variation across tissues and development.
Nature communications - 15 Apr 2026
Rosenski Jonathan, Sabag Ofra, Marcus Eitan, Loyfer Netanel, Dor Yuval, Cedar Howard, Kaplan Tommy
Abstract excerpt
The mechanisms by which genetic variation shapes the epigenome across cell types and developmental stages have remained elusive. Here, we define a unifying developmental framework for DNA methylation programming, grounded in genome-wide methylation and genetic variation data from both mouse and human. In mice, we identify thousands of differentially methylated regions (DMRs) linked to sequence polymorphisms that...
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