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STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.

The Journal of biological chemistry - 1 Jun 2024

Xu Wanying, Kim Jung-Sik, Yang Tianyi, Ya Alvin, Sadzewicz Lisa, Tallon Luke, Harris Brent T, Sarkaria Jann, Jin Fulai, Waldman Todd

Abstract excerpt

Inactivating mutations of genes encoding the cohesin complex are common in a wide range of human cancers. STAG2 is the most commonly mutated subunit. Here we report the impact of stable correction of endogenous, naturally occurring STAG2 mutations on gene expression, 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme (GBM). In two GBM cell lines, correction of their STAG2...

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Antigens, Nuclear
Brain Neoplasms
Cell Cycle Proteins
Chromatin
Cohesins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycomb-Group Proteins

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Open in PubMed Open full text

Identifiers

PMID: 38705393
DOI: 10.1016/j.jbc.2024.107341
PMCID: PMC11157269

Genes

STAG2
STAG1
HEPH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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