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STAG2 loss in Ewing sarcoma alters enhancer-promoter contacts dependent and independent of EWS::FLI1

1 Nov 2024

Abstract excerpt

Cohesin complexes carrying STAG1 or STAG2 organize the genome into chromatin loops. STAG2 loss-of-function mutations promote metastasis in Ewing sarcoma, a pediatric cancer driven by the fusion transcription factor EWS::FLI1. We integrated transcriptomic data from patients and cellular models to identify a STAG2-dependent gene signature associated with worse prognosis. Subsequent genomic profiling and...

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Histiocytic Disorders and Treatments
Sarcoma Diagnosis and Treatment
Urologic and reproductive health conditions

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39487368
DOI: 10.1038/s44319-024-00303-6

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