Article

Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells

2026-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Truncating mutations in the tumor suppressor STAG2 , which encodes a component of the cohesin complex, are prevalent across diverse human cancers. Here, we report that acute reconstitution of physiological STAG2 levels in STAG2 -mutant human glioblastoma multiforme cancer cells triggers a rapid reduction in the size of chromatin loops genome-wide. Despite this global change in chromatin loop s...

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Literature Corpus work: 1c6657bf-beb7-5689-befe-35f7f123f00b
DOI: 10.64898/2026.05.26.727913

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