Article
STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.
Cell reports - 27 Aug 2024
Fischer Alexander, Hernández-Rodríguez Benjamín, Mulet-Lazaro Roger, Nuetzel Margit, Hölzl Fabian, van Herk Stanley, Kavelaars François G, Stanewsky Hanna, Ackermann Ute, Niang Amadou H, Diaz Noelia, Reuschel Edith, Strieder Nicholas, Hernández-López Inmaculada, Valk Peter J M, Vaquerizas Juan M, Rehli Michael, Delwel Ruud, Gebhard Claudia
Abstract excerpt
Cohesin shapes the chromatin architecture, including enhancer-promoter interactions. Its components, especially STAG2, but not its paralog STAG1, are frequently mutated in myeloid malignancies. To elucidate the underlying mechanisms of leukemogenesis, we comprehensively characterized genetic, transcriptional, and chromatin conformational changes in acute myeloid leukemia (AML) patient samples. Specific loci...
Topics
- Humans
- Cohesins
- Leukemia, Myeloid, Acute
- Cell Cycle Proteins
- Chromatin
- Chromosomal Proteins, Non-Histone
- Mutation
- Hematopoietic Stem Cells
- Cell Differentiation