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Article

Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells.

The Journal of biological chemistry - 1 Aug 2026

Yang Tianyi, Kim Jung-Sik, Mellows Clara, Xu Wanying, Ya Alvin, Sadzewicz Lisa, Tallon Luke, Sarkaria Jann, Jin Fulai, Waldman Todd

Abstract excerpt

Truncating mutations in the tumor suppressor STAG2, which encodes a component of the cohesin complex, are prevalent across diverse human cancers. Here, we report that acute reconstitution of physiological STAG2 levels in STAG2-mutant human glioblastoma multiforme cancer cells triggers a rapid reduction in the size of chromatin loops genome-wide. Despite this global change in chromatin loop size, early...

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Share to Antigens, Nuclear
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cohesins

Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 42336286
DOI: 10.1016/j.jbc.2026.113288
PMCID: PMC13393664

Genes

STAG2
EFEMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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