Article

Chronic Loss of STAG2 Leads to Altered Chromatin Structure Contributing to DE-Regulated Transcription in AML.

2020-08-20

Abstract excerpt

<title>Abstract</title> <p>Background The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex member. Methods Here we use functional genomics (RNA-seq, ChIP-seq and HiChIP) to investigate the...

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Literature Corpus work: 584a2736-982b-5fdf-8a5f-b87d17f0bdd6
DOI: 10.21203/rs.3.rs-30641/v2

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