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Article

STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer.

PloS one - 1 Jan 2025

Park Youngrok, Xu Wanying, Yang Tianyi, Hill Victoria, He Xiaoyuan, Sadzewicz Lisa, Tallon Luke, Kim Jung-Sik, Jin Fulai, Waldman Todd

Abstract excerpt

The STAG2 tumor suppressor gene is commonly inactivated by mutations in a wide range of common cancer types. STAG2 encodes a component of the cohesin complex, which controls sister chromatid cohesion and 3D genome organization. In bladder cancer, STAG2 mutations are most common in the earliest low-grade lesions, suggesting that mutational inactivation of STAG2 may be an initiating event. To provide insight into...

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Share to Cell Cycle Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Cohesins

Share to Gene Expression Regulation, Neoplastic

Share to Polycomb-Group Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 41091719
DOI: 10.1371/journal.pone.0333128
PMCID: PMC12527211

Genes

STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer.PMID 41091719Read ↗

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