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Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous System

2024-09-14

Abstract excerpt

The identification of specific markers to distinguish resident microglia from infiltrating monocytes has been a long-standing challenge in neuroscience. Recently, proteins such as P2RY12, TMEM119, and FCRLS have been proposed as microglia-specific and are now widely used to define microglial populations in health and disease. The specificity of these markers was predicated on the assumption that circulating monocy...

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Literature Corpus work
c4bb96cf-4187-5f36-8b25-1f29455d41d5
DOI
10.1101/2024.09.09.612126
Open publication

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Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous SystemDOI 10.1101/2024.09.09.612126
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