Article

CD11c <sup>+</sup> CD88 <sup>+</sup> CD317 <sup>+</sup> myeloid cells are critical mediators of persistent CNS autoimmunity

2020-06-11

Abstract excerpt

<h4>Background</h4> Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c + cells should curtail their migration to the CNS and ameliorate experimental autoimmune encephalomyelitis (EAE). <h4>Methods</h4> We generated CD11c.Cre +/- ITGA4 fl/fl C57/...

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Literature Corpus work: e5334a41-aca0-55d8-8202-1dfbdf7d3c77
DOI: 10.1101/2020.06.10.144956

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