Article

Hepatic <i>huntingtin</i> loss drives an acute phase response and liver injury in multiple mouse models

2026-07-29

Abstract excerpt

Multiple therapeutic strategies are being developed to slow Huntington’s disease (HD) progression through targeted reduction of huntingtin (HTT) protein or mRNA. Despite HTT’s discovery over 30 years ago, its cellular functions remain incompletely understood, and the long-term consequences of HTT-lowering therapies remain unclear. We previously demonstrated that hepatic HTT loss in mice disrupts hepatocyte zonatio...

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Literature Corpus work: c877c384-8349-5238-b888-558aa1563aac
DOI: 10.64898/2026.07.28.741358

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