Article

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

2023-06-26

Abstract excerpt

Huntington’s disease arises from a toxic gain of function in the huntingtin ( HTT ) gene. As a result, many HTT-lowering therapies are being pursued in clinical studies, including those that reduce HTT RNA and protein expression in the liver. To investigate potential impacts, we characterized molecular, cellular, and metabolic impacts of chronic HTT lowering in mouse hepatocytes. Lifelong hepatocyte HTT loss is...

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Identifiers and source

Literature Corpus work: 715edfcc-e0b4-5949-b2f6-a69ada3132fd
DOI: 10.1101/2023.06.24.546334

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