Article

METTL3-IGF2BP3 m⁶A axis drives mutant huntingtin stability and neurodegeneration in Huntington’s disease

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the <italic>HTT</italic> gene, yet the molecular mechanisms linking mutant huntingtin (mHTT) to selective neuronal vulnerability remain incompletely understood. Emerging evidence suggests that post-transcriptional RNA regulation plays a role in HD pathogenesis; however, the contrib...

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Literature Corpus work: e3a0138a-3983-5c6d-908d-0b66853fcb59
DOI: 10.21203/rs.3.rs-9928562/v1

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