Article

Liver Zonation Disruption Fuels Hepatocellular Carcinoma in Chronic Liver Disease

2025-12-10

Abstract excerpt

<h4>Summary</h4> Hepatocellular carcinoma (HCC) arises almost exclusively in chronic liver disease (CLD), yet the classical etiological drivers of injury insufficiently explain why only a subset of patients progress to cancer. Here, we identify disruption of liver metabolic zonation, specifically, aberrant expansion of β-catenin activity from pericentral to periportal territories as a previously unrecognized tumo...

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Literature Corpus work: 72189f52-5623-5ccb-9b87-360bc82e8fe2
DOI: 10.64898/2025.12.06.692782

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