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Article

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.

Life science alliance - 1 Nov 2023

Bragg Robert M, Coffey Sydney R, Cantle Jeffrey P, Hu Shikai, Singh Sucha, Legg Samuel Rw, McHugh Cassandra A, Toor Amreen, Zeitlin Scott O, Kwak Seung, Howland David, Vogt Thomas F, Monga Satdarshan P, Carroll Jeffrey B

Abstract excerpt

Huntington's disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a result, many HTT-lowering therapies are being pursued in clinical studies, including those that reduce HTT RNA and protein expression in the liver. To investigate potential impacts, we characterized molecular, cellular, and metabolic impacts of chronic HTT lowering in mouse hepatocytes. Lifelong hepatocyte HTT loss is...

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PMID: 37684045
DOI: 10.26508/lsa.202302098
PMCID: PMC10488683

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