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Article

A neuroprotective phase precedes striatal degeneration upon nucleolar stress

14 Jun 2013

Abstract excerpt

The nucleolus is implicated in sensing and responding to cellular stress by stabilizing p53. The pro-apoptotic effect of p53 is associated with several neurodegenerative disorders, including Huntington's disease (HD), which is characterized by the progressive loss of medium spiny neurons (MSNs) in the striatum. Here we show that disruption of nucleolar integrity and function causes nucleolar stress and is an...

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PMID: 23764776
DOI: 10.1038/cdd.2013.66

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