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Article

Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models.

Annals of the New York Academy of Sciences - 1 Dec 2008

Browne Susan E

Abstract excerpt

A mechanistic link between cellular energetic defects and the pathogenesis of Huntington's disease (HD) has long been hypothesized based on the cardinal observations of progressive weight loss in patients and metabolic defects in brain and muscle. Identification of respiratory chain deficits in HD postmortem brain led to the use of mitochondrial complex II inhibitors to generate acute toxicity models that...

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Identifiers

PMID: 19076457
DOI: 10.1196/annals.1427.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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