Article

snRNA-seq of Huntington’s disease mice reveals vulnerability profiles of cortical cell types

2025-12-02

Abstract excerpt

A common feature of neurodegeneration is selective vulnerability, where certain neurons succumb to disease, while others remain spared. The molecular underpinnings of these differences remain elusive. Here, we performed transcriptomic profiling of the motor cortex in a mouse model of Huntington’s disease (HD), an incurable hereditary movement disorder caused by a CAG repeat expansion in the Huntingtin gene. Striki...

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Literature Corpus work: ddd993bb-dea6-572e-880d-0154d44aa266
DOI: 10.1101/2025.11.28.691138

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