Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific

Abstract excerpt

<h4>Summary</h4> Cells counteract proteotoxic conditions by launching transcriptional stress responses. While synthesis of Heat shock proteins (HSPs) upon acute stress is well-characterized, how distinct proteotoxic conditions reshape the transcriptome remains poorly understood. Here, we analyse polyA+ RNA expression under heat shock, HSP90 inhibition, and polyglutamine (polyQ) aggregation. We find fundamentally...

Topics

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• Amyotrophic Lateral Sclerosis Research
• Climate Change and Health Impacts
• Genetic Neurodegenerative Diseases
• Genetics, Aging, and Longevity in Model Organisms
• Heat shock proteins research
• Hereditary Neurological Disorders
• Spaceflight effects on biology
• Thermoregulation and physiological responses

Identifiers and source

Literature Corpus work

74789b77-a7e4-5ceb-a3b3-aa9787b1c5b4

DOI

10.64898/2025.12.17.694942