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Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy Failure

2026-08-24

Abstract excerpt

Huntington disease (HD) is caused by a polyglutamine expanded huntingtin protein that exerts progressive cellular toxicity. However, the temporal sequence of pathogenic, particularly early and reversible versus late and irreversible events remain incompletely defined, despite their distinct therapeutic implications. To delineate this trajectory, we profiled the proteome of a huntingtin expressing cell model at ear...

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Literature Corpus work: 49e29f81-ee58-5ce9-9978-79ac5e312be9
DOI: 10.64898/2026.08.21.746221

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Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy FailureDOI 10.64898/2026.08.21.746221Read

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