Article

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Recent studies demonstrated that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as NR2F2) is an important regulator of glucose and lipid metabolism. Its contribution to organ fibrosis is undefined. Here, we found increased COUP-TFII expression in my...

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Literature Corpus work: c825d7eb-4a53-5bd5-aeb5-97ef4e0ac0de
DOI: 10.1101/2020.06.05.135889

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