Article

Tissular glucocorticoid reactivating enzyme 11β-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease

2025-01-13

Abstract excerpt

Chronic kidney disease (CKD) is a growing public health crisis, affecting over 10% of the global population and significantly increasing mortality and morbidity. Irrespective of its underlying cause, tubulointerstitial fibrosis (TIF) is a hallmark of CKD progression, with myofibroblasts being the primary effectors of renal fibrosis. Here, we show that 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a crit...

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Literature Corpus work: 0d2160bc-9836-5382-8004-8261e8f32167
DOI: 10.1101/2025.01.09.631985

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