Article

ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis is a fatal disease characterized by the TGF-β-dependent activation of lung fibroblasts, leading to excessive deposition of collagen proteins and progressive replacement of healthy lung with scar tissue. We and others have shown that fibroblast activation is supported by metabolic reprogramming, including the upregulation of the de novo synthesis of glycine, the mos...

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Literature Corpus work: e2a95970-1dc6-597d-beed-a8914f633fd4
DOI: 10.1101/2024.06.12.598694

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