Article

<i>Jagged1/Notch2</i> Controls Kidney Fibrosis via <i>Tfam</i> -mediated Metabolic Reprogramming

2018-03-29

Abstract excerpt

While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and receptor pair that are responsible for kidney disease remain poorly defined. In this study, we found that JAG1 and NOTCH2 showed the strongest correlation with the degree of interstitial fibrosis in a genome wide expression analysis of a large cohort of huma...

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Literature Corpus work: 98d2a3ba-f278-5079-978f-c30d71f17c2a
DOI: 10.1101/285726

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