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Article

Human Transcriptomic Validation of a Proximal Tubule–Fibrogenic Interstitial Pyrimidinergic Axis in Kidney Disease

2026-03-18

Abstract excerpt

<h4>Background: </h4> Kidney fibrosis develops through sustained communication between injured tubular epithelial cells and surrounding interstitial populations. In our recent mechanistic study, we identified a pyrimidinergic pathway linking injury-associated proximal tubule metabolism to P2Y6-mediated fibroblast activation. Here, we sought to determine whether this biological axis is also detectable in human kidn...

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Literature Corpus work
a0a1cea8-f2db-5214-af97-c4099ca773f9
DOI
10.20944/preprints202603.1435.v1
Open publication

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Human Transcriptomic Validation of a Proximal Tubule–Fibrogenic Interstitial Pyrimidinergic Axis in Kidney DiseaseDOI 10.20944/preprints202603.1435.v1
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