Article

Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney

2023-11-10

Abstract excerpt

<h4>Background</h4> Tissue fibrosis is a common feature of many organ dysfunctions, such as heart failure and chronic kidney disease. However, no fundamental treatment has been developed. This study aims to identify novel molecular mechanisms for antifibrotic intervention, focusing on fibroblast activation. <h4>Methods</h4> We performed a forward genetic screen using a genome-wide CRISPR library in the context o...

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Literature Corpus work: 8b1171c5-29fd-5f64-8f31-ca84bae7e665
DOI: 10.1101/2023.11.09.566496

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Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidneyDOI 10.1101/2023.11.09.566496Read

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