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Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

22 Mar 2023

Abstract excerpt

OBJECTIVE: In the fibrotic kidneys, the extent of a formed deleterious microenvironment is determined by cellular mechanical forces. This process requires metabolism for energy. However, how cellular mechanics and metabolism are connected remains unclear. METHODS: A multi-disciplinary approach was employed: the fibrotic kidney disease models were induced by renal ischemia-reperfusion injury and unilateral...

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PMID: 36963615
DOI: 10.1016/j.molmet.2023.101712

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