Article
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.
Circulation - 11 Oct 2016
Li Min, Riddle Suzette, Zhang Hui, D'Alessandro Angelo, Flockton Amanda, Serkova Natalie J, Hansen Kirk C, Moldovan Radu, McKeon B Alexandre, Frid Maria, Kumar Sushil, Li Hong, Liu Hongbing, Caánovas Angela, Medrano Juan F, Thomas Milton G, Iloska Dijana, Plecitá-Hlavatá Lydie, Ježek Petr, Pullamsetti Soni, Fini Mehdi A, El Kasmi Karim C, Zhang QingHong, Stenmark Kurt R
Abstract excerpt
BACKGROUND: Changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells, including fibroblasts, in pulmonary hypertension (PH). Here, we test the hypothesis that metabolic reprogramming to aerobic glycolysis is a critical adaptation of fibroblasts in the hypertensive vessel wall that drives proliferative and proinflammatory activation through a mechanism involving...
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