Article

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

2019-06-18

Abstract excerpt

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and control biological processes, including fibrogenesis. Kidney fibrosis remains a clinical challenge and miRNAs may represent a valid therapeutic avenue. We show that miR-9-5p protected from renal fibrosis in the mouse model of unilateral ureteral obstruction (UUO). This was reflected in reduced expression of pro-fibrotic markers, decreased numbe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: faa3799a-9f7c-5d7b-9ce6-c5393db281ac
DOI: 10.1101/667972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-9-5p protects from kidney fibrosis by metabolic reprogrammingDOI 10.1101/667972Read

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasisSemantic proximity Read

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic PathwaysSemantic proximity Read

Ablation of the Renal Tubular Gluconeogenic Enzyme PCK1 Drives AKI-to-CKD Transition by Negatively Regulating the TGF-β/Smad3 Signaling PathwaySemantic proximity Read

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosisSemantic proximity Read

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice.Semantic proximity Read

PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic RegulatorSemantic proximity Read

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosisSemantic proximity Read

Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responsesSemantic proximity Read

<i>Jagged1/Notch2</i> Controls Kidney Fibrosis via <i>Tfam</i> -mediated Metabolic ReprogrammingSemantic proximity Read

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosisSemantic proximity Read

Evidence for the involvement of epigenetics in the progression of renal fibrogenesisSemantic proximity Read

GDNF-engineered AMSC-derived exosomes attenuate renal interstitial fibrosis by promoting peritubular capillary regeneration via miR-29c-3p–IFN-γ–SIRT1 signalingSemantic proximity Read