Article

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosis

2026-06-22

Abstract excerpt

Fibrotic extracellular matrix (ECM) is not merely a structural scaffold but an instructive signaling interface that shapes epithelial cell state. However, the molecular cues by which matrix remodeling controls tubular metabolism during kidney fibrosis remain poorly defined. Here, we identify Fibulin-2 (FBLN2) as a fibroblast-derived matrix cue that transduces fibrotic ECM remodeling into tubular mitochondrial meta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96367194-40d6-5c3a-9670-63ba2cf64ad1
DOI: 10.64898/2026.06.19.733428

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosisDOI 10.64898/2026.06.19.733428Read

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosisSemantic proximity Read

<i>Jagged1/Notch2</i> Controls Kidney Fibrosis via <i>Tfam</i> -mediated Metabolic ReprogrammingSemantic proximity Read

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosisSemantic proximity Read

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity Read

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity Read

Role of HAO2 in rats with chronic kidney disease by regulating fatty acid metabolic processes in renal tissueSemantic proximity Read

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasisSemantic proximity Read

β-catenin-regulated Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosisSemantic proximity Read

Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease targetSemantic proximity Read

MiR-9-5p protects from kidney fibrosis by metabolic reprogrammingSemantic proximity Read

Multi-Omics Integration Reveals Lipid Metabolic Reprogramming as a Driver of Cystogenesis in Autosomal Dominant Polycystic Kidney Disease (ADPKD)Semantic proximity Read

Human Transcriptomic Validation of a Proximal Tubule–Fibrogenic Interstitial Pyrimidinergic Axis in Kidney DiseaseSemantic proximity Read