Article

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

2023-01-03

Abstract excerpt

In the fibrotic kidneys, the extent of a formed deleterious microenvironment is determined by cellular mechanical forces. This process requires metabolism for energy; however, how cellular mechanics and metabolism are connected remains unclear. Our proteomics revealed that actin filament binding and cell metabolism are the two most dysregulated events in the fibrotic kidneys. As a prominent actin stabilizer, Calpo...

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Literature Corpus work: b0b63c8b-bf53-5d8f-a46b-6cf5bc3c9743
DOI: 10.1101/2023.01.03.522608

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