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Calcineurin inhibition deactivates pyruvate dehydrogenase and induces proximal tubule cell metabolic dysfunction, causing profibrotic phenotype

2024-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Calcineurin inhibitors (CNIs) are indispensable immunosuppressants for transplant recipients and patients with autoimmune diseases, but chronic use causes nephrotoxicity, including kidney fibrosis. Why inhibiting calcineurin, a serine/threonine phosphatase, causes kidney fibrosis remains unknown. We performed single-nucleus RNA sequencing of the kidney from a chronic CNI nephrotoxicity mouse mod...

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Literature Corpus work
a675eb22-1159-583d-9429-28dd0b104d73
DOI
10.1101/2024.11.20.624584
Open publication

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Calcineurin inhibition deactivates pyruvate dehydrogenase and induces proximal tubule cell metabolic dysfunction, causing profibrotic phenotypeDOI 10.1101/2024.11.20.624584
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