Article

Transcriptional Network Dysregulation in Alzheimer’s Disease Revealed by Individual-Specific Gene Regulatory Models

2025-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder marked by progressive cognitive decline, yet its transcriptional regulatory architecture remains poorly understood. Here, we model sample-specific gene regulatory networks (GRNs) from dorsolateral prefrontal cortex transcriptomes of 87 individuals with AD and 67 non-cognitively impaired (NCI) controls using PANDA and LIONESS...

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Literature Corpus work: 6241fb01-44ef-55b6-bac3-b150f91fe167
DOI: 10.1101/2025.03.26.25324703

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