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Article

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease.

PLoS computational biology - 1 Jul 2022

Gupta Chirag, Xu Jielin, Jin Ting, Khullar Saniya, Liu Xiaoyu, Alatkar Sayali, Cheng Feixiong, Wang Daifeng

Abstract excerpt

Dysregulation of gene expression in Alzheimer's disease (AD) remains elusive, especially at the cell type level. Gene regulatory network, a key molecular mechanism linking transcription factors (TFs) and regulatory elements to govern gene expression, can change across cell types in the human brain and thus serve as a model for studying gene dysregulation in AD. However, AD-induced regulatory changes across brain...

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PMID: 35849618
DOI: 10.1371/journal.pcbi.1010287
PMCID: PMC9333448

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