Article

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer’s disease lipid-processing microglia

2026-07-14

Abstract excerpt

Lipid-processing microglia are among the microglial states most strongly associated with Alzheimer’s disease (AD) pathology, yet whether this association reproduces across independent cohorts, what transcriptional programs define the state, and which upstream signals and small molecules can modulate it remain unsolved. We address these questions through a cross-cohort analysis of one such substate (MG4) by integra...

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Literature Corpus work: 069b5d03-18f6-5583-aebd-647571986f30
DOI: 10.64898/2026.07.10.737805

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