Article

Senescent and disease-associated microglia are modifiable features of aged brain white matter

2023-10-30

Abstract excerpt

<title>Abstract</title> <p>Brain white matter tracts undergo structural and functional changes linked to late-life cognitive decline, but the cellular and molecular contributions to their selective vulnerability are not well defined. In naturally aged mice, we demonstrate that senescent and disease-associated microglia (DAM) phenotypes converge in hippocampus-adjacent white matter. Through gold-standard gene expr...

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Literature Corpus work: c766a99f-40bd-5a51-aa87-e9a22d07424a
DOI: 10.21203/rs.3.rs-3467812/v1

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