Article
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
Nature neuroscience - 1 Mar 2016
Grabert Kathleen, Michoel Tom, Karavolos Michail H, Clohisey Sara, Baillie J Kenneth, Stevens Mark P, Freeman Tom C, Summers Kim M, McColl Barry W
Abstract excerpt
Microglia have critical roles in neural development, homeostasis and neuroinflammation and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration often occurs in disease-specific, spatially restricted patterns, the origins of which are unknown. We performed to our knowledge the first genome-wide analysis of microglia from discrete brain regions across the adult lifespan of the...
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