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Article

West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex.

Biomolecules - 8 Jul 2024

Arutyunov Artem, Durán-Laforet Violeta, Ai Shenjian, Ferrari Loris, Murphy Robert, Schafer Dorothy P, Klein Robyn S

Abstract excerpt

Microglia, the resident macrophages of the central nervous system, exhibit altered gene expression in response to various neurological conditions. This study investigates the relationship between West Nile Virus infection and microglial senescence, focusing on the role of LGALS3BP, a protein implicated in both antiviral responses and aging. Using spatial transcriptomics, RNA sequencing and flow cytometry, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39062523
DOI: 10.3390/biom14070808
PMCID: PMC11274721

Genes

LGALS3BP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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