Article

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex

2025-02-20

Abstract excerpt

<h4>Summary</h4> Identifying senescent cells poses challenges due to their rarity, heterogeneity, and lack of a definitive marker. We performed Visium spatial transcriptomics (ST) and single nucleus RNA sequencing (snRNA-seq) on non-pathological human tissue to build a transcriptomic atlas of aging and senescence in the dorsolateral prefrontal cortex (dlPFC). We identified markers characteristic of aging dlPFC co...

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Literature Corpus work: 29e0625b-79fd-59fa-a890-d684f885ad72
DOI: 10.1101/2025.02.19.639091

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