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Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

2023-03-10

Abstract excerpt

<h4>Background</h4> Microglia, the brain’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males. Although sex differences in microglial function and transcriptomic programming have been described across development and in disease models of AD, no studies have comprehensively identified the sex divergences that emerge in t...

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Literature Corpus work
3d722a75-9814-52b1-8e71-65aa3a011061
DOI
10.1101/2023.03.07.531562
Open publication

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Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s diseaseDOI 10.1101/2023.03.07.531562
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