Article
Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype.
Communications biology - 23 Jun 2023
Matsudaira Tatsuyuki, Nakano Sosuke, Konishi Yusuke, Kawamoto Shimpei, Uemura Ken, Kondo Tamae, Sakurai Koki, Ozawa Takaaki, Hikida Takatoshi, Komine Okiru, Yamanaka Koji, Fujita Yuki, Yamashita Toshihide, Matsumoto Tomonori, Hara Eiji
Abstract excerpt
Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular stresses, is critically involved in age-related tissue dysfunction in various organs. However, the features of cells in the central nervous system that undergo senescence and their role in neural impairment are not well understood as yet. Here, through comprehensive investigations utilising single-cell transcriptome...
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