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Article

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

1 Jan 2013

Abstract excerpt

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and age-related macular degeneration (AMD), share two characteristics in common: (1) a disease prevalence that increases markedly with advancing age, and (2) neuroinflammatory changes in which microglia, the primary resident immune cell of the CNS, feature prominently. These characteristics have led to the hypothesis that pathogenic...

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PMID: 23493481
DOI: 10.3389/fncel.2013.00022

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