Article

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the Brain

2025-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Aging and cerebrovascular pathology drive neuroinflammation in vascular dementia (VaD) but immune mechanisms underlying this interplay remain unresolved. Leveraging multi-modal high-dimensional imaging, flow cytometry, and split pool ligation transcriptomic sequencing in a mouse model of VaD, we constructed a brain immune cell atlas spanning young and aged mice in health and disease. We profiled...

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Literature Corpus work: 2f32e62b-3951-514b-bda2-25db8c8d4ad5
DOI: 10.64898/2025.12.10.693494

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