Article

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations

2025-07-29

Abstract excerpt

The proliferation and phenotypic modulation of smooth muscle cells (SMCs) to alternative mesenchymal states is a key process by which atherosclerotic lesions grow. The underlying mechanisms can be studied in mouse and pig atherosclerosis, but it remains unclear to what extent the mesenchymal plaque cell types in these species recapitulate human disease. Here, we integrate published and new single-cell RNA sequenci...

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Literature Corpus work: 25f4c62c-8b45-5228-834a-f92537300426
DOI: 10.1101/2025.07.24.666663

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