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CD8+ T Cells Drive Plaque Smooth Muscle Cell Dedifferentiation in Experimental Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2024

Schäfer Sarah, Gogiraju Rajinikanth, Rösch Melanie, Kerstan Yvonne, Beck Lina, Garbisch Janine, Saliba Antoine-Emmanuel, Gisterå Anton, Hermanns Heike M, Boon Louis, Kastenmüller Wolfgang, Schäfer Katrin, Cochain Clément, Zernecke Alma

Abstract excerpt

BACKGROUND: Atherosclerosis is driven by the infiltration of the arterial intima by diverse immune cells and smooth muscle cells (SMCs). CD8+ T cells promote lesion growth during atherosclerotic lesion development, but their role in advanced atherosclerosis is less clear. Here, we studied the role of CD8+ T cells and their effects on SMCs in established atherosclerosis. METHODS: CD8+ T cells were depleted in (SMC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38868941
DOI: 10.1161/ATVBAHA.123.320084

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