Article

A rare pre-existing progenitor-like Primed SMC compartment is the dominant inferred source of SMC-derived cellularity in vascular injury and atherosclerosis

2026-06-29

Abstract excerpt

The cellular origin of smooth muscle cell (SMC)-derived populations in vascular lesions remains unresolved. Here we show, using single-cell transcriptomic analyses spanning carotid ligation injury, Myh11-CreERT²-traced aortic homeostasis, and LDLR- and ApoE-deficient atherosclerosis, that a rare progenitor-like “Primed” SMC compartment pre-exists at baseline in all models and in the healthy human aorta. Relative t...

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Literature Corpus work: ca47e1f8-8508-5beb-8fe4-ddfd36ea0fa3
DOI: 10.64898/2026.06.28.735042

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