Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries

Abstract excerpt

The process of arterial atherosclerosis is characterised by accumulation of lipids and fibrous material with accompanying inflammation. As plaques progress, they restrict blood flow and cause rupture, which results in life threatening organ ischemia and dysfunction. Although extensively studied, a clear understanding of plaque heterogeneity and mechanisms that trigger their destabilization remains elusive. Ou...

Topics

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• Carotid Artery Diseases
• Cell Transdifferentiation
• Chromatin Immunoprecipitation Sequencing
• Myeloid Cells
• Myocytes, Smooth Muscle
• Plaque, Atherosclerotic
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

cdc615fb-af43-589a-83ce-2c4dc8e59f4f

DOI

10.1101/2025.04.16.649077